Left Ventricular Volumes, Mass and Function normalized to the body surface area, age and gender from CMR in a large cohort of well-treated Thalassemia Major patients without myocardial iron overload
نویسندگان
چکیده
A. Meloni, M. C. Dell'Amico, B. Favilli, G. D. Aquaro, P. Festa, E. Chiodi, S. Renne, G. Restaino, V. Positano, M. C. Galati, M. Lombardi, and A. Pepe Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology, Pisa, Italy, Arcispedale “S. Anna”, Ferrara, Italy, P.O. “Giovanni Paolo II”, Lamezia Terme, Italy, Università Cattolica del Sacro Cuore, Campobasso, Italy, A.O. "Pugliese-Ciaccio", Catanzaro, Italy
منابع مشابه
Right Ventricular Volumes and Function normalized to body surface area, age and sex in a large cohort of well-treated Thalassemia Major without myocardial iron overload
Right Ventricular Volumes and Function normalized to body surface area, age and sex in a large cohort of well-treated Thalassemia Major without myocardial iron overload Antonella Meloni, Maria Chiara Dell’Amico, Brunella Favilli, Giovanni D Aquaro, Ait-Ali Lamia, Elisabetta Chiodi, Claudio Ascioti, Stefania Renne, Pier Paolo Bitti, Calogera Gerardi, Vincenzo Positano, Massimo Lombardi, Alessia ...
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Abstract Background Myocardial iron overload is the leading cause of death in patients with beta-thalassemia major. Combined therapy with deferiprone(DFP) and desferrioxamine (DFO)were suggested to be more effective than deferasirox(DFX) for removing heart iron. Deferasirox has recently been made available, but its long-term efficacy on cardiac function has not yet been established. Our study...
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Abstract Objective Cardiac dysfunction is a major cause of death in patients with beta thalassemia. In these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. Left ventricular ejection fraction was measured in major beta thalassemia (β-Th) patients to detect the rela...
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Background: Cardiac dysfunction due to chronic anemia and hemosiderosis are the major causes of death among patients with thalassemia intermedia. This study was performed to compare the cardiac function in thalassemia intermedia patients with normal subjects by means of echocardiography. Materials and Methods: This was a case-control study performed on 22 patients affected by thalassemia int...
متن کاملDifferent patterns of myocardial iron overload by multislice T2* Cardiovascular MR as markers of risk for cardiac dysfunction in thalassemia major
Methods 1135 TM patients (538 M, mean age 30 ± 19 years) enrolled in the Myocardial Iron Overload in Thalassemia (MIOT) network underwent CMR (1.5 T). For the assessment of MIO, three short-axis views of the left ventricle (LV) were acquired and the myocardium was segmented into 16-segments standardized LV model. The T2* value on each segment was calculated as well as the global T2* value. A co...
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